ArticleCerebral circulation - cognition and behavior2026
Comparison of cognitive decline rates and risk factors between stroke and non - stroke populations: An analysis of data from the China health and retirement longitudinal study (CHARLS).
Article in Cerebral circulation - cognition and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to longitudinally compare cognitive decline trajectories between stroke and non-stroke populations, and identify key risk factors associated with accelerated cognitive deterioration. Methods: Data were extracted from the 2011 baseline and 2020 follow-up waves of the China Health and Retirement Longitudinal Study (CHARLS). After excluding participants with missing cognitive assessment data, stroke status information, or follow-up data, a total of 6810 eligible participants were included. Cognitive function was evaluated using a composite score integrating episodic memory and executive function, ranging from 0 to 21. Univariate and multivariate logistic regression models were used to identify risk factors for cognitive decline, and a nomogram was constructed to visualize the combined effect of key variables. Results: At baseline (2011), there was no significant difference in cognitive function scores between the stroke and non-stroke groups (median: 13 vs. 13.5, P = 0.307). However, after 10 years of follow-up, the stroke group exhibited a significantly faster cognitive decline rate (median change: 6% vs. 3.1%, P = 0.031), with a higher proportion of cognitive decline (62.4%vs. 51.1%, P < 0.05). Multivariate logistic regression analysis revealed that Cystatin C (CysC; β=0.461, OR=1.585, 95% CI: 1.154-2.177, P < 0.05), low-density lipoprotein (LDL; β=0.002, OR=1.002, 95% CI: 1.000-1.004, P < 0.05) and blood urea nitrogen (BUN; β=0.018, OR=1.018, 95% CI: 1.002-1.034, P < 0.05)were independent risk factors for cognitive decline in the total population. In the stroke subgroup, hypertension was associated with cognitive decline (OR = 4.250, 95% CI: 1.169-15.454, P = 0.028). Conclusion: Compared with stroke-free individuals, stroke patients experienced a faster rate of cognitive decline. CysC, LDL, and BUN are reliable risk predictors of cognitive deterioration in the general elderly population, while hypertension correlates with post-stroke cognitive decline.
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