ReviewBioactive materials2026
Post-translational modification-regulating biomaterials for regeneration.
Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-translational modification (PTM) refers to covalent chemical alterations occurring on proteins after their biosynthesis, encompassing phosphorylation, acetylation, ubiquitination and hundreds of other documented variants. These modifications act as dynamic molecular codes that precisely regulate protein subcellular localization, functional activity and interaction networks. Through core biological processes like signal transduction and metabolic regulation, they ultimately define cellular identity while maintaining adaptive responses to environmental stimuli. Emerging evidence links PTM dysregulation to various disease pathways, where impaired tissue regeneration emerges as a strategic intervention window for targeted PTM-based therapies. As core components of regenerative medicine, biomaterials with designable physicochemical properties can achieve precise PTM regulation through physicochemical signal transduction, overcoming conventional limitations and providing innovative platforms for tissue regeneration. This review analyzes how intrinsic material properties, surface modifications and ROS-regulating capabilities influence PTM control, while exploring the potential of biomaterials in precision PTM modulation. We then focus on advancements in bone, vascular, muscle and neural regeneration, demonstrating how biomaterial-mediated PTM regulation enables tissue-specific repair. Finally, we discuss current challenges and propose bioengineering strategies for advanced PTM control.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.