Evidence map›Paper›PMID 42494755›Full record

ArticleBioactive materials2026

Ultrasonic-driven force-electric nanodomains orchestrate lysosome-to-mitochondria functional cascade to accelerate bone regeneration.

Linbo Zhang, Pandong Lin, Dandan Wang, Xue Wang, Kangqing Zuo, Taixing Zhang, Wen Luo, Jing Li, Yinchuan Wang, Ke Ma and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Linbo ZhangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Pandong LinKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Ji'nan, 250061, PR China.
Dandan WangCollege of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China.
Xue WangMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China.
Kangqing ZuoDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Taixing ZhangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Wen LuoCollege of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China.
Jing LiDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Yinchuan WangSchool of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong Province, 250117, PR China.
Ke MaDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Yilin ZhangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Shengjun SunDepartment of Prosthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, 250012, PR China.
Guiyong XiaoKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Ji'nan, 250061, PR China.
Yupeng LuKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Ji'nan, 250061, PR China.
Dongsheng ZhangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Shengyun HuangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.
Bing HanSchool of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, 250117, PR China.
Ningbo LiDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong Province, 250021, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Piezoelectric materials offer a promising bioinspired direction for bone regeneration by mimicking the native electromechanical environment of bone. However, existing studies mainly focus on extracellular piezoelectric cues perceived by cell membrane, while whether force-electric signals can be precisely regulated at subcellular functional units governing osteogenesis remains insufficiently understood. Here, we report an ultrasound-activated force-electric regulation strategy enabled by ultrafine LiNbO

Indexed as

Bone regenerationIntracellular piezoelectric nanodomainsSubcellular structuresUltrafine LiNbO3 nanoparticlesUltrasound activation

Identifiers

PMID42494755
PMCPMC13393310

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.