ReviewBiomaterials research2026
Plant-Derived Exosomes in Aesthetic Medicine.
Review in Biomaterials research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global cosmetic surgery industry is actively seeking alternatives that can overcome the limitations of traditional animal-derived exosomes, which face clinical translation bottlenecks including high costs, immunological risks, and zoonotic disease hazards. Plant-derived exosomes (PLDEs) offer a promising attractive "green" nanotechnology platform owing to their inherent safety, minimal immunogenicity, and suitability for scalable manufacturing. Their core advantage lies in delivering plant-specific bioactive compounds (such as small RNAs and secondary metabolites) that target multiple key signaling pathways, including skin aging, pigmentation, inflammation, and regeneration, through cross-species regulatory mechanisms. This review critically synthesizes PLDE biological basis, isolation methods, and evidence for antiaging, skin brightening, and regenerative efficacy. It delineates how surface functionalization, targeted drug delivery, and biomaterial integration (hydrogels and microneedles) optimize PLDE targeting. Finally, it addresses current challenges in clinical translation and standardization, offering a forward-looking perspective on the development of next-generation PLDE-based therapies for minimally invasive aesthetic applications.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.