Evidence map›Paper›PMID 42495072›Full record

ArticleFrontiers in cardiovascular medicine2026

Association of triglyceride glucose index with cardiovascular autonomic neuropathy in type 2 diabetes mellitus.

Feijuan Kong, Ziqi Wang, Qiyu Yang, Jingzhu Wu, Shanshan Tang, Mingyu Gu, Xiaoying Ding, Yufan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Feijuan Kong *Department of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Shanghai, China.
Ziqi Wang *School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Qiyu Yang *Department of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Shanghai, China.
Jingzhu WuDepartment of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Shanghai, China.
Shanshan TangDepartment of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Shanghai, China.
Mingyu GuDepartment of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Shanghai, China.
Xiaoying DingDepartment of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Shanghai, China.
Yufan WangDepartment of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Medical College of Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiovascular autonomic neuropathy (CAN), defined as impaired autonomic control of the cardiovascular system, is a highly prevalent yet frequently underdiagnosed microvascular complication of diabetes. The triglyceride-glucose (TyG) index, a well-validated surrogate marker of insulin resistance, may have considerable clinical relevance for CAN. Nevertheless, the association between the TyG index and CAN in patients with type 2 diabetes mellitus (T2DM) remains unclear. Methods: A total of 230 hospitalized patients with T2DM were recruited from the Department of Endocrinology and Metabolism, Shanghai General Hospital. CAN status was evaluated using the cardiovascular autonomic reflex test (CART) and heart rate variability (HRV) measurements. Meanwhile, demographic characteristics and relevant clinical data were collected, and the TyG index was calculated based on fasting blood glucose and triglyceride levels for subsequent statistical analysis. Results: The prevalence of CAN in our cohort of 230 patients was 61.3% (141 cases). Patients with CAN exhibited a significantly higher TyG index compared to those without CAN. The TyG index demonstrated positive correlations with CART parameters (E:I difference, Conclusions: The TyG index shows a distinct association with CAN assessment parameters. As a well-established, effective, and practical surrogate marker of IR, this finding highlights the clinical relevance of the TyG index in diabetes-related complications.

Indexed as

cardiovascular autonomic neuropathydiabetic complicationsinsulin resistancetriglyceride glucose indextype 2 diabetes mellitus

Identifiers

PMID42495072
PMCPMC13391583

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.