ArticleFrontiers in cardiovascular medicine2026
Comparative analysis of myocardial strain parameters in acute decompensated heart failure phenotypes: a cross-sectional study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the differences in two-dimensional speckle tracking echocardiography (2D-STE) parameters among patients with different types of acute decompensated heart failure (ADHF) and their correlation with left ventricular ejection fraction (LVEF). Methods: Ninety-eight patients hospitalized due to ADHF were included in this study. Patients were divided into two subgroups based on their LVEF using a cutoff of ≤49%: heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). All patients underwent transthoracic echocardiography and 2D-STE. Results: Compared to the HFrEF group,the HFpEF group showed significantly higher absolute values of GLSA4C, GLSA2C, GLSA3C, and LV-GLS values ( Conclusion: Significant differences exist in 2D-STE parameters between the HFrEF and HFpEF groups, and LVEF correlates with these parameters. After adjusting for LVEF, LV-GLS remains correlated with various parameters in different heart failure groups. Our findings suggest a stronger interdependence between right ventricular and left atrial mechanics in HFpEF patients compared to HFrEF patients, evidenced by the persistence of correlations between RV free wall strain and LA reservoir/pump strain after adjusting for LVEF.
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