ArticleFrontiers in microbiology2026
Integrated gut microbiota and metabolome analyses link anger to metabolic dysregulation in patients with type 2 diabetes mellitus.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This exploratory pilot study aimed to investigate the associations of anger-related irritability symptoms with gut microbiota and circulating metabolites in patients with type 2 diabetes mellitus (T2DM) using multi-omics analysis. Methods: We conducted a cross-sectional study, in which T2DM patients were categorized into a self-reported irritable T2DM group (IDM, Results: Both beta diversity and LEfSe analyses revealed differences in gut microbial community structure and potential discriminatory taxa among the three groups. Five differentially abundant genera and twelve exploratory metabolite markers were identified between IDM and NIDM. A combined model incorporating microbial and metabolomic markers demonstrated superior diagnostic performance (AUC = 0.872) compared with models using either type of marker alone. Twelve statistically significant microbiota-metabolite associations were found in Spearman analysis. Functional prediction analysis indicated enrichment of bile acid and tryptophan metabolism pathways. Conclusion: VAS-defined irritability symptoms were associated with specific gut microbial and metabolomic alterations in T2DM, providing exploratory evidence for future studies on emotion-related metabolic dysregulation.
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