Evidence map›Paper›PMID 42495535›Full record

ArticleiScience2026

Antiretroviral regimen and sex-specific metabolic heterogeneity in pediatric HIV.

Chandre Herbert, Louise Kuhn, Nicole H Tobin, Fan Li, Renate Strehlau, Faeezah Patel, Tian Wang, Shuang Wang, Grace M Aldrovandi, Caroline T Tiemessen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chandre HerbertNational Institutes for Communicable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Louise KuhnGertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Nicole H TobinDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.
Fan LiDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.
Renate StrehlauVIDA Nkanyezi Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Faeezah PatelWits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tian WangGertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Shuang WangGertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Grace M AldrovandiDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.
Caroline T TiemessenNational Institutes for Communicable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Funding

Host epigenetic and mitochondrial function in HIV-infected childrenR01HD073952 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2012 to 2016
$3.7M
Bone health in perinatally HIV-infected South African children on antiretroviralsR01HD073977 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPADI, STEPHEN M, YIN, MICHAEL T · 2012 to 2016
$3.6M
Oral microbial signatures in perinatal HIV infectionR01DE028135 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2018 to 2021
$2.5M
NICHD NIH HHS R01 HD073952NICHD NIH HHS R01 HD073977NIDCR NIH HHS R01 DE028135
6 · The paper itself

Abstract

Host metabolism is increasingly recognized as relevant in HIV remission and cure research yet remains understudied in children living with perinatally acquired human immunodeficiency virus (CLWH). The relation between clinical factors and plasma metabolic profiles, generated by untargeted ultra high-performance liquid chromatography/tandem mass spectrometry, of pre-pubescent, virally suppressed CLWH (

Indexed as

antiretroviral therapychildren living with HIVHIV curemetabolomicsmetabotypesmitochondriaperinatally acquired HIVprepubescentsexual dimorphismvirally suppressed

Identifiers

PMID42495535
PMCPMC13393711

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.