ArticleAnnals of medicine2026
Early hemodynamic assessment and longitudinal imaging for predicting graft outcomes post-transplant.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundThe early identification of early allograft dysfunction (EAD) and the long-term prediction of graft-related adverse event-free survival (GRAEFS) are crucial for effective post-transplant management.
methodsThe study encompassed two complementary analyses: (1) an early hemodynamic assessment, which evaluated the diagnostic efficacy of hepatic artery ultrasound parameters for the identification of EAD; and (2) a longitudinal imaging prognostic analysis, which developed radiomics and Vision Transformer Base/16-based (Vit b/16) nomograms utilizing Delta features extracted from serial grayscale ultrasound images at six key time points relative to day 1, for the prediction of 3-year GRAEFS. The performance of the models was externally validated and compared with clinical baseline models.
resultsA hepatic artery resistive index (RI) below 0.55 within 4 days post-transplant is linked to EAD, showing a high negative predictive value (92.2%) for ruling out EAD. The Vit b/16 nomogram excelled in predicting 3-year GRAEFS, with AUCs of 0.951, 0.847, and 0.831 in training, internal, and external validation cohorts, respectively, surpassing the radiomics nomogram. In external validation, it outperformed the best clinical model (AUC: 0.831 vs. 0.808,
conclusionThis study shows that a drop in the hepatic artery RI soon after surgery is linked to EAD, and a Vit b/16-based nomogram from ultrasound images effectively predicts 3-year GRAEFS. These results need prospective validation before clinical use.
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