Evidence map›Paper›PMID 42496959›Full record

ReviewAdvanced biotechnology2026

Metabolic engineering of cereal lipids: from omega-3 fatty acids to wax esters and pheromones.

Meng-Tian Li, Jia-Ting Lin, Pedro García-Caparros, Li-Hua Zhu, Nan Yao, Yi-Han Xia

Abstract readReview
In one paragraph

Review in Advanced biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meng-Tian Li *Guangdong Provincial Key Laboratory of Plant Stress Biology, State Key Laboratory of Biocontrol, School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, 518107, People's Republic of China.
Jia-Ting Lin *School of Life Sciences, Sun Yat-sen University, Shenzhen, 510275, People's Republic of China.
Pedro García-CaparrosDepartment of Superior School Engineering, University of Almería, Almería, Spain.
Li-Hua ZhuDepartment of Plant Breeding, Swedish University of Agricultural Sciences, Lomma, Sweden.
Nan YaoSchool of Life Sciences, Sun Yat-sen University, Shenzhen, 510275, People's Republic of China. yaonan@mail.sysu.edu.cn.
Yi-Han XiaGuangdong Provincial Key Laboratory of Plant Stress Biology, State Key Laboratory of Biocontrol, School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, 518107, People's Republic of China. xiayh23@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-4213-9524

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515110553Innovative Research Group Project of the National Natural Science Foundation of China 32502572Shenzhen Science and Technology Innovation Program JCYJ20250604175303005
6 · The paper itself

Abstract

Cereals are emerging as attractive platforms for the sustainable production of high-value lipids through metabolic engineering. Although plant lipids play essential biological roles and have considerable economic value, their conventional production from natural sources is often limited by sustainability, scalability and cost. Recent advances in synthetic biology enable the reprogramming of seed lipid metabolism for the tailored synthesis of valuable lipid compounds. In this review, we first summarize the core pathways of fatty acid biosynthesis and triacylglycerol assembly in seeds, together with the genetic transformation and genome editing toolkits available for major cereals. We then highlight recent progress in the heterologous production of specialized lipids, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), wax esters, and insect sex pheromones, in engineered plant systems. Finally, we discuss the potential of cereals as scalable and sustainable platforms for the production of high-value lipids. Together, these advances position engineered cereals as promising plant-based factories for applications in agriculture, nutrition, and the emerging bio-based economy.

Indexed as

CerealInsect pheromonesLipid metabolismPUFAsWax esters

Identifiers

PMID42496959
PMCPMC13400530

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.