Evidence map›Paper›PMID 42497247›Full record

ArticleScience advances2026

ELF3 links kidney function GWAS loci to maladaptive epithelial inflammation.

Yanjuan Hou, Konstantin Kloetzer, Bernhard Dumoulin, Eunji Ha, Hongbo Liu, Dhanunjay Mukhi, Magaiver Andrade-Silva, Xuemei Hu, Siyu Pan, Katalin Susztak

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanjuan HouRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-5197-7394
Konstantin KloetzerRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0009-0005-5022-2706
Bernhard DumoulinRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Eunji HaRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-8618-8347
Hongbo LiuRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-0733-8616
Dhanunjay MukhiRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-6179-5220
Magaiver Andrade-SilvaRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-5135-0981
Xuemei HuRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Siyu PanRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-2493-265X
Katalin SusztakRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-1005-3726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have uncovered over a thousand loci associated with kidney function, but the effector genes and mechanisms remain largely unknown. Here, we demonstrate that

Indexed as

DNA-Binding ProteinsGenome-Wide Association StudyInflammationKidneyProto-Oncogene Proteins c-etsRenal Insufficiency, ChronicTranscription FactorsAnimalsDisease Models, AnimalEpithelial CellsGene Expression RegulationHumansKidney Tubules, ProximalMiceNF-kappa BDNA-Binding ProteinsELF3 protein, humanElf3 protein, mouseNF-kappa BProto-Oncogene Proteins c-etsTranscription Factors

Identifiers

PMID42497247
PMCPMC13398524

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.