ArticleScience advances2026
Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
Podocytes (PODs) play a critical role in maintaining glomerular filtration function, and their injury is a key driver of progressive podocytopathies (PCPs). Despite their clinical importance, the molecular and spatial mechanisms underlying POD injury remain poorly understood. We generated a single-nucleus RNA sequencing (snRNA-seq) and high-resolution spatial transcriptomic (ST) dataset from kidney tissues of patients with five major PCP subtypes. Our analysis revealed distinct molecular signatures among PCP subtypes, injury-related cytoskeletal alterations, and POD-centered microenvironmental features associated with clinical outcomes. Through integrative analysis, we found
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