In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Xinhang ZhengShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-7714-5142 Zhifang ZhaoShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Yuchen XuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-6394-2968 Lu BaiShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Mingxiao LangShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Wenfeng ShanShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0001-3512-4615 Ying WangShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhiyuan WangShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Yujun DengShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0005-0559-4981 Shanshan QiuBio-breeding Center, Zhejiang Seed Industry Group Xinchuang bio-breeding Co., Ltd., Hangzhou 310000, China.ORCID 0000-0002-0625-8083 Han GaoDepartment of Plant Pathology, The Ministry of Agriculture Key Laboratory of Pest Monitoring and Green Management, and Joint International Research Laboratory of Crop Molecular Breeding (Ministry of Education), China Agricultural University, Beijing 100193, China.ORCID 0000-0001-9472-9836 Bingbing WanKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-8629-0616 Houxiang KangState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.ORCID 0000-0002-9538-4646 Yangwen QianWIMI Biotech Co., Ltd., Sanya 572000, China.
Gongyou ChenShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-1979-2880 Jiangbo FanShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-8952-8861 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Plant surface immune receptors are tightly controlled to maintain homeostasis and prevent overactivation. However, the mechanisms coordinating the balance remain largely unknown. The monocot-specific receptor-like kinase SDS2 regulates cell death and immunity in rice. Here, we identify Thr671, a conserved phospho-switch in RD-type Ser/Thr kinases across kingdoms, as the central node that orchestrates both immune activation and turnover of SDS2. Autophosphorylation of Thr671 initiates signaling but also primes SDS2 for ubiquitination and degradation by the E3 ligase SPL11. This degradation is antagonized by the phosphatase SIPP1, which stabilizes SDS2 through Thr671 dephosphorylation to promote immunity. Strikingly, a second phosphatase, SIPP2, displaces SIPP1 from SDS2 via competitive binding, thereby enabling SPL11-dependent SDS2 degradation and ensuring timely immune attenuation. Thus, the SIPP1-SPL11-SIPP2 module establishes a dynamic equilibrium essential for SDS2 homeostasis, providing new insights into the sophisticated regulation of surface receptors.
Indexed as
HomeostasisOryzaPlant ImmunityPlant ProteinsProtein KinasesEnzyme ActivationPhosphorylationProteolysisSignal TransductionUbiquitinationPlant ProteinsProtein Kinases
Identifiers
PMID42497276
PMCPMC13398521
What Socratic holds
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