ReviewMedicine2026
Global research trends in gastroesophageal reflux disease and depression: A bibliometric analysis.
Review in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between gastroesophageal reflux disease (GERD) and depression has received increasing attention, but the knowledge structure of this field remains insufficiently summarized. This study aimed to analyze global trends, hotspots, and frontier directions in GERD and depression research using bibliometric methods.
methodsEnglish articles and reviews related to GERD and depression that were published between January 1, 2000, and December 31, 2024, were retrieved from Web of Science. After screening and duplicate removal, 636 publications were included. R software, VOSviewer, and CiteSpace were used for bibliometric analysis and visualization.
resultsAnnual publication output in GERD and depression research showed an overall upward trend, indicating growing research attention in this field. The United States contributed the largest number of publications, followed by China, Australia, Japan, and South Korea. The University of California was the most productive institution. Talley NJ was the most productive author, while Fass R was the most frequently co-cited author. Neurogastroenterology and Motility published the most studies, whereas the American Journal of Gastroenterology had the highest citation frequency. Keyword and thematic evolution analyses showed that "quality of life," "comorbidities," "Mendelian randomization," "inflammation," and "brain-gut axis" were important themes. Research hotspots mainly focused on the causal relationship between GERD and depression, the impact of comorbidity on quality of life, and potential mechanisms such as inflammation and the brain-gut axis.
conclusionThis bibliometric analysis outlined the knowledge structure and developmental trends in GERD and depression research. Future studies should further clarify the bidirectional association and biological mechanisms linking GERD and depression, while strengthening research on quality of life and comprehensive management strategies for patients with comorbid conditions.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.