ArticleMedicine2026
Association of dietary fiber with all-cause mortality in U.S. adults with diabetes: Mediating role of the systemic immune-inflammation index.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary fiber is recommended in diabetes management for its potential anti-inflammatory effects, but currently, the association between fiber intake, systemic inflammation, and long-term survival in adults with diabetes remains uncertain. This cohort study analyzed data from 3894 U.S. adults with diabetes across 10 National Health and Nutrition Examination Survey cycles (1999-2020). Fiber intake levels (grams of fiber per kilogram of body weight, g/kg) was assessed via dietary interviews, and mortality outcomes were linked to National Death Index records through 2019. The systemic immune-inflammation index (SII) was calculated using platelet, neutrophil, and lymphocyte counts. Cox proportional hazards models evaluated associations between fiber intake and all-cause mortality, adjusted for demographics, lifestyle factors, and comorbidities. Mediation analysis quantified SII's role in mortality risk reduction. Higher fiber intake levels demonstrated a dose-dependent inverse relationship with all-cause mortality (P < .001). In fully adjusted models, the 3rd quartile (Q3) of fiber intake levels showed the lowest mortality risk (hazard ratio = 0.47, 95% confidence interval = 0.37-0.68). The association attenuated slightly in Q4, possibly indicating a threshold effect. Mediation analysis revealed that 13.07% (95% confidence interval = 6.85%-18%) of the mortality reduction was attributable to SII downregulation. Increased dietary fiber intake levels are associated with reduced all-cause mortality in diabetic populations, with a possible mediating factor being the reduction in systemic inflammation levels among U.S. adults with diabetes. These findings support integrating fiber-rich diets into diabetes management protocols.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.