Evidence map›Paper›PMID 42499153›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study.

Brittany N Dugger, Melanie N Luu, Viharkumar Patel, Charles DeCarli, Lee-Way Jin, Paola Gilsanz, Dan Mungas, Claudia Kawas, Maria M Corrada, Rachel A Whitmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brittany N DuggerUniversity of California, Davis, Sacramento, California, USA.
Melanie N LuuUniversity of California, Davis, Sacramento, California, USA.
Viharkumar PatelUniversity of California, Davis, Sacramento, California, USA.
Charles DeCarliUniversity of California, Davis, Sacramento, California, USA.
Lee-Way JinUniversity of California, Davis, Sacramento, California, USA.
Paola GilsanzKaiser Permanente Northern California, Division of Research, Pleasanton, California, USA.
Dan MungasUniversity of California, Davis, Sacramento, California, USA.
Claudia KawasUniversity of California, Irvine, Irvine, California, USA.
Maria M CorradaUniversity of California, Irvine, Irvine, California, USA.
Rachel A WhitmerUniversity of California, Davis, Sacramento, California, USA.

Funding

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldR01AG056519 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Maria Corrada, Paola Gilsanz · 2022 to 2026
$25.8M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
NIA NIH HHS P30 AG072972NIA NIH HHS P30AG072972NIA NIH HHS R01 AG056519NIA NIH HHS R01AG056519
6 · The paper itself

Abstract

introductionStudies of the oldest-old show great neuropathologic heterogeneity; little is known in diverse populations after age 90.

methodsLifeAfter90 is a lifecourse cohort study of individuals aged ≥ 90 years evaluated every 6 months with optional brain donation; this study presents initial neuropathological findings.

resultsA total of 124 decedents (mean age 96, 49.2% White, 12.1% Black, 16.9% Asian, 18.5% Latino individuals) came to autopsy. At last evaluation, 35% had dementia, 23% cognitive impairment, and 41% normal cognition. 35.5% had intermediate AD, 8.1% had high AD neuropathologic changes, 73% had moderate/severe arteriolosclerosis, 23% one or more microinfarcts, 32% Lewy bodies, 24% TDP-43 deposits, and 4% hippocampal sclerosis. There was a high degree of mixed neuropathology, with 69% having three or more pathologies. Cognitive impairment was most strongly associated with AD pathology. DISCUSSION: Multiple pathologies were common, and many individuals maintained normal cognition indicating substantial neuropathologic burden may be present in the absence of overt cognitive impairment, especially in the oldest-old.

Indexed as

Alzheimer DiseaseBrainAged, 80 and overCognitive DysfunctionCohort StudiesFemaleHippocampal SclerosisHumansMaleNeuropathologyagingamyloidcardiovascular diseasecentenariancognitivedementianeuropathologytau

Identifiers

PMID42499153
PMCPMC13400840

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.