ReviewJournal of the International AIDS Society2026
Durability of the Humoral Response to MPXV Infection.
Review in Journal of the International AIDS Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Towards Elimination of Sexually Transmitted Infections: Research Developments and Vaccine Uptake.Journal of the International AIDS Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMpox virus (MPXV) re-emerged in endemic countries in recent decades, resulting in large outbreaks in central and western Africa and a worldwide epidemic of clade IIb MPXV starting in 2022. Mpox cases in vaccinated persons, and a few documented reinfections, have raised questions about the durability of MPXV humoral immunity. Longitudinal studies conducted during the clade IIb global outbreak have enriched our understanding of immune responses during and after mpox. This commentary aims to summarize current knowledge about the durability of humoral immunity against MPXV and limitations in the available evidence. DISCUSSION: Studies following convalescent individuals show vigorous neutralizing antibody titres that peak within weeks after symptom onset and remain detectable for up to 2 years following acquisition. Binding IgG and IgA antibodies directed against MPXV antigens peak and wane more rapidly. Immunodominant epitopes, such as A35R, elicit robust responses. Older individuals who received historical replicating smallpox vaccines and acquired mpox had higher neutralizing and binding antibody titres than younger people, with no apparent difference in durability of humoral immune markers. In some studies, people living with HIV had less vigorous early antibody responses than people without HIV but without an observed difference in durability.
conclusionsLong-term protection following mpox involves both humoral and cellular immunity. There is no identified correlate of protection for mpox. The current evidence primarily includes studies of mild to moderate clade IIb infection among cohorts largely comprising men in non-endemic countries. Research involving additional viral clades and cohorts with greater breadth of geography, age, gender, race, ethnicity and severity of disease is needed to more fully explore durability of the MPXV immune response. A more complete understanding of this complex picture would likely inform development of improved vaccines and therapeutics for mpox.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.