ReviewAnnals of medicine2026
Beyond hyperglycaemia: diabetic retinopathy is a multifactorial complication of diabetes mellitus.
Review in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe remarkable researches have been made to clarify the pathogenesis of DR, but relatively little is known about it. The goal was to summarize the epidemiology and mechanism of DR, provide screening and biomarker information of DR and suggest the strategies for treatment and intervention of DR.
methodsThis article synthesizes recent findings on intricate interrelated patho-physiological mechanisms elicited by hyperglycaemia underlie the progression of DR.
resultsDR has long been considered a microvascular disorder, but accumulating evidences demonstrate that retinal neurodegeneration like activated microglial is involved as well. The progression of DR is underpinned by complex, interconnected pathophysiological mechanisms triggered by hyperglycaemia, including vascular endothelial growth factor (VEGF), methylglyoxal (MGO), Wnt signalling pathways, retinal neurodegeneration and other factors. Enhanced comprehension of the fundamental pathophysiological mechanisms, coupled with advancements in computer technology, fosters the development of innovative approaches to screening, diagnosis and early intervention for DR.
conclusionDR, a multifactorial complication of diabetes mellitus, necessitates continued research into precise screening methodologies and targeted therapeutic strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.