Evidence map›Paper›PMID 42499337›Full record

ArticleJournal of the Endocrine Society2026

Nuclear mitochondrial interaction test reveals sex-dependent mitochondrial SNP-Klotho interactions on diabetes risk.

Tae Jung Oh, Hiroshi Kumagai, Kelvin Yen, Eileen M Crimmins, Thalida E Arpawong, Pinchas Cohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tae Jung OhDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, Korea.
Hiroshi KumagaiLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Kelvin YenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Eileen M CrimminsLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Thalida E ArpawongLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Pinchas CohenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.ORCID https://orcid.org/0000-0002-0035-8366

Funding

Ethnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and DementiaR01AG068405 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS, CRIMMINS, EILEEN M · 2020 to 2024
$3.6M
NIA NIH HHS R01 AG068405
6 · The paper itself

Abstract

Context: Environmental or other genetic factors might influence the effect of Objective: We investigated mitochondrial genetic variants that interact with Methods: We used the data from 7047 non-Hispanic White participants of the Health and Retirement Study, a prospective observational study including adults aged 50 years and older from the United States. First, we performed single gene-wide association scans to identify Results: We failed to identify a significant association between diabetes and the Conclusion: The NuMIT approach revealed significant interactions between mitochondrial and nuclear DNA variants of

Indexed as

diabetes mellitusKlothomitochondriasexsingle nucleotide polymorphism

Identifiers

PMID42499337
PMCPMC13397116

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.