ReviewJPRAS open2026
The fate of the neuromuscular junction in peripheral nerve injury - current understanding and future research aims: A scoping review.
Review in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: Peripheral nerve injury (PNI) represents a challenging frontier for the many surgical specialties dealing with these injuries. Improved surgical techniques and understanding have resulted in improvements in patient care, but a mastery of the processes of nerve regeneration and repair have proved elusive. Objective: This review intends to outline the changes at the neuromuscular junction in response to denervation injury. By reviewing the current literature, we aim to solidify the understanding of these morphological changes and identify future areas of research need. Review: A literature search of PubMed, Embase and Web of Science including studies up to 22nd December 2023 was carried out. Search terms related to the motor endplate or neuromuscular junction, nerve degeneration, peripheral nerve injury and nerve regeneration. Three researchers independently performed screening of potentially relevant studies, using Findings: We identified 3595 records in the initial search, with no additional articles identified through backward and forward citation tracking. 350 full-text reports were assessed for eligibility. Ultimately, 118 studies were included for data extraction. Conclusions and Relevance: The mechanisms of degeneration and regeneration at the NMJ summarized within provide multiple opportunities for ongoing research. Terminal Schwann cells and the constituents of the post synaptic apparatus may be able to be induced to survive for longer, or to be replenished to levels facilitating functional recovery from greater periods of denervation.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.