ArticleFrontiers in pediatrics2026
Value of thyroid volume as a complementary indicator for initial levothyroxine dosing in congenital hypothyroidism: a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to generate hypotheses on the effectiveness and safety of pre-treatment thyroid volume as an adjunctive parameter for guiding initial levothyroxine (L-T4) dosing in children with congenital hypothyroidism (CH). Methods: This retrospective study included children diagnosed with CH at Huizhou First Maternal and Child Health Hospital (2021-2023). Based on first follow-up ultrasound thyroid volume, patients were divided into reduced (A, Results: At screening and before treatment, both Group A and Group C had significantly higher TSH levels and lower FT4 levels than Group B (all Conclusion: These findings suggest that children with CH and abnormal thyroid volume may require higher initial L-T4 doses and a longer time to TSH normalization. Based on these observations, we propose the following hypothesis: thyroid volume, as an adjunct to thyroid function tests in guiding initial dosing regimens, holds certain research value in clinical practice. Future prospective, multicenter, and large-sample studies are required to validate this hypothesis.
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