ArticleWorld journal of otorhinolaryngology - head and neck surgery2026
An Experimental Study on the Protective Effect of Memantine in Noise-Induced Hearing Loss.
Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objective: This study examined the potential protective effects of memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods: Thirty guinea pigs with normal hearing were divided into six groups ( Results: Baseline ABR thresholds were < 30 dB SPL, and DPOAE SNRs were ≥ 6 dB. Group 6 showed improved DPOAE SNRs at 1.5 and 24 kHz compared to Groups 3 and 5. ABR thresholds in Group 6 were lower than those in Group 3 (16, 24 kHz) and Group 5 (32 kHz). Group 4 showed lower thresholds than Group 3 at 12-24 kHz. Histology revealed milder cochlear damage in Group 6 compared to Groups 2, 3, and 5. Conclusion: Memantine demonstrated protective effects against noise-induced hearing loss. Further studies are needed to clarify its molecular mechanisms.
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