Evidence map›Paper›PMID 42500104›Full record

ArticleWorld journal of otorhinolaryngology - head and neck surgery2026

Obstructive Sleep Apnea and BMI, Body Fat Percentage in the East Asian Population: A Bidirectional and Multivariate Mendelian Randomization Study.

Rui Fan, Wen-Jun Lu, Hua Zhang, Hai-Ling Jiang, Tao Li, Yan Yan

Abstract read
In one paragraph

Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rui FanDepartment of Otorhinolaryngology Peking University Third Hospital Beijing China.ORCID https://orcid.org/0009-0000-4948-3507
Wen-Jun LuDepartment of Otorhinolaryngology Peking University Third Hospital Beijing China.ORCID https://orcid.org/0000-0002-8806-9058
Hua ZhangClinical Epidemiology Research Center, Peking University Third Hospital Beijing China.
Hai-Ling JiangDepartment of Otorhinolaryngology Peking University Third Hospital Beijing China.
Tao LiDepartment of Otorhinolaryngology Peking University Third Hospital Beijing China.
Yan YanDepartment of Otorhinolaryngology Peking University Third Hospital Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the causal relationship between obstructive sleep apnea and body fat percentage and body mass index (BMI) in the East Asian population by using bidirectional Mendelian randomization and multivariate Mendelian randomization. Methods: We utilized genetic data on obstructive sleep apnea and BMI from the NBDC database in Japan and body fat percentage data from the Biobank in Taiwan, China. Obstructive sleep apnea cases were identified using ICD-10 diagnostic codes rather than PSG data. Concurrently, body fat percentage and BMI were inferred from genetic variants rather than from actual body fat percentage or BMI measurements. Bivariate and multivariate Mendelian randomization analyses assessed the causal relationship between obstructive sleep apnea and obesity. The Inverse Variance Weighted method was used as the main Mendelian randomization analysis method. Results: In this study, we found that for the East Asian population (a) the forward causal relationship between body fat percentage and obstructive sleep apnea was significant (Inverse Variance Weighted: Conclusions: Both body fat percentage and BMI are strong risk factors for obstructive sleep apnea, and body fat percentage can function independently of BMI. Body fat percentage may be able to be used as a new indicator for screening and diagnosis of obstructive sleep apnea.

Indexed as

BMIbody fat percentageMendelian randomizationobstructive sleep apnea

Identifiers

PMID42500104
PMCPMC13399181

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.