ArticleFrontiers in nutrition2026
Relationship between berry intake and frailty in the elderly and the mediating role of six blood markers: based on Chinese and American studies.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Frailty has become a major public health challenge with the acceleration of global aging. Berries are rich in bioactive components, but the mechanism and population-specific association with frailty is not clear. Methods: For Chinese populations, data from hospitalized patients at Pidu District People's Hospital during May-July 2024 were analyzed using the Frailty phenotype (FP) to evaluate frailty. This study employed the 24-h dietary recall method from the 2003-2008 National Health and Nutrition Examination Survey (NHANES) database to assess berry consumption. A frailty index (FI) was calculated using approximately 49 indicators to determine frailty status. The research utilized a weighted regression model to investigate the relationship between berry intake and frailty severity, while examining the mediating role of six blood biomarkers through mediation analysis. Results: This study enrolled 357 Chinese elderly individuals and 5,553 American adults aged 65 and older. The findings in China demonstrated that berry consumption was associated with reduced frailty risk. This association remained statistically significant even after adjusting for other potential confounding factors. In the NHANES, compared to individuals who did not consume berries, daily berry intake ranging from 37-74 grams and 74-158 grams was associated with reduced risks of frailty, and these associations remained statistically significant after adjustment for other confounding factors. Notably, this association was more pronounced among males. Mediation analysis indicated that HbA1c levels mediated 6.64% of the effect. Conclusion: This study demonstrates that berry consumption is associated with a lower risk of frailty. Particularly for males, incorporating berries into dietary intervention strategies targeting this population may offer potential benefits; additionally, glycated hemoglobin (HbA1c) could serve as an indicator for efficacy monitoring in subsequent interventional studies.
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