Evidence map›Paper›PMID 42500264›Full record

ArticlePediatric discovery2026

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway.

Meiling Chen, Chenxi Jia, Zhuocheng Shi, Bianan Zhu, Yihang Yu, Xing Liu, Feng Liu, Jianwei Chen, Tao Xu, Yuanyuan Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meiling ChenMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.
Chenxi JiaMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.
Zhuocheng ShiMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.
Bianan ZhuMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.
Yihang YuMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.
Xing LiuMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.
Feng LiuDepartment of Pediatric Urology West China Second University Hospital, Sichuan University Chengdu Sichuan China.
Jianwei ChenCenter for Bio-Intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in Shenzhen, Tsinghua University Shenzhen Guangdong China.
Tao XuCenter for Bio-Intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in Shenzhen, Tsinghua University Shenzhen Guangdong China.
Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine Winston-Salem North Carolina USA.
Deying ZhangMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.ORCID https://orcid.org/0009-0004-8488-2967
Guanghui WeiMinistry of Education Key Laboratory of Child Development and Disorders, Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Chongqing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal fibrosis is a common pathological feature and key driver of progression to end-stage renal disease in various chronic kidney diseases, with effective treatments remaining scarce. Exosomes derived from mesenchymal stem cells (MSC-Exos) have demonstrated tremendous potential in tissue and organ repair and antifibrosis treatment. This study investigated the therapeutic effects and mechanisms of MSC-Exo derived from human umbilical cord (HucMSC-Exo) on renal fibrosis. HucMSC-Exo was applied to intervene in a mouse model of renal fibrosis induced by unilateral ureteral obstruction (UUO) or cocultured with TGF-β-stimulated rat renal fibroblasts (NRK-49F). Results showed that HucMSC-Exo conspicuously alleviated pathological damage, inflammatory response, fibroblast proliferation/activation, and extracellular matrix deposition in UUO kidneys. Single-cell sequencing revealed a prominent upregulation of

Indexed as

exosomesfibroblast activationINHBAmesenchymal stem cellsPI3K/AKT signaling pathwayrenal fibrosis

Identifiers

PMID42500264
PMCPMC13398571

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.