SynthesisFrontiers in psychiatry2026
Diagnostic stability and long-term outcomes of acute and transient psychotic disorders: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Background: To examine the diagnostic stability and long-term outcomes of acute and transient psychotic disorders (ATPD), with particular attention to subsequent diagnostic transitions and relapse over time. Methods: A systematic search of PubMed, Embase, Web of Science, the Cochrane Library, as well as Chinese databases including CNKI, Wan fang, and VIP, was conducted from database inception to March 1, 2026. Observational studies reporting follow-up outcomes in patients initially diagnosed with ATPD were eligible. Data extraction and quality assessment were performed independently by two reviewers. Pooled proportions were estimated using random-effects models, and statistical analyses were conducted using R software (version 4.5.1). Results: A total of 14 studies involving 12,920 participants were included. The pooled proportion of diagnostic stability was 0.41 (95% CI: 0.34-0.51), while 0.50 (95% CI: 0.36-0.63) of patients experienced any diagnostic change. Transition to schizophrenia spectrum disorders occurred in 0.39 (95% CI: 0.29-0.50) of cases, whereas transition to mood disorders was less frequent (0.19, 95% CI: 0.12-0.30). The pooled relapse rate was 0.43 (95% CI: 0.29-0.58). Conclusions: ATPD appears to show limited diagnostic stability, with a considerable proportion of patients experiencing diagnostic change over time. Transitions to schizophrenia spectrum disorders are relatively common, whereas affective outcomes are less frequent. However, substantial heterogeneity across studies limits the certainty of these estimates. These findings underscore the need for cautious interpretation of early diagnoses and highlight the importance of longitudinal follow-up. Further prospective studies with standardized methodologies are warranted. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261347946, identifier CRD420261347946.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.