Evidence map›Paper›PMID 42500490›Full record

ArticleFrontiers in bioengineering and biotechnology2026

pH- and calcium-dependent solution-phase free fluoride in dental desensitizing gels: a preliminary in vitro study.

Paweł J Piszko, Michał J Kulus, Aleksandra Piszko, Jan Kiryk, Sylwia Kiryk, Julia Kensy, Agata Małyszek, Mateusz Michalak, Wojciech Dobrzyński, Jacek Matys and 1 more

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Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paweł J PiszkoDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Wroclaw, Poland.
Michał J KulusDivision of Ultrastructural Research, Wroclaw Medical University, Wroclaw, Poland.
Aleksandra PiszkoDepartment of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Wroclaw, Poland.
Jan KirykDental Surgery Department, Wroclaw Medical University, Wroclaw, Poland.
Sylwia KirykDepartment of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Wroclaw, Poland.
Julia KensyDepartment of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Wroclaw, Poland.
Agata MałyszekDepartment of Biostructure and Animal Physiology, Wrocław University of Environmental and Life Sciences, Wroclaw, Poland.
Mateusz MichalakMedical Center of Innovation, Wroclaw Medical University, Wroclaw, Poland.
Wojciech DobrzyńskiDepartment of Dentofacial Orthopedics and Orthodontics, Division of Facial Abnormalities, Wroclaw Medical University, Wroclaw, Poland.
Jacek MatysDental Surgery Department, Wroclaw Medical University, Wroclaw, Poland.
Maciej DobrzyńskiDepartment of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Wroclaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dental hypersensitivity (DH) is a common clinical condition characterized by brief, intense pain. This condition is treated with fluoride-containing specialized dental gels. The effect of calcium ions present in saliva and pH of the oral cavity are indicated as factors affecting their clinical performance. Methods: In the presented study, two dental desensitizing gels were evaluated. Fourier Transform Infrared Spectroscopy (FTIR) spectra of the gels were registered and analyzed. Measurement of concentration of measurable free fluoride ions and pH Results and Discussion: The highest values of free, measurable fluoride were obtained after addition of TISAB with CDTA. However, in physiological study without ionic strength adjuster and chelator, the highest free, measurable fluoride observed in the artificial saliva solutions was 1,043 ppm for the SensiKIN desensitizing gel at pH 4.5 in the solution without calcium ion addition. The lowest value (658 ppm) was denoted for the Teeth Desensitiser TD gel at pH 7.0 with calcium ion addition. The presented amounts of fluoride pertain to measurable free fluoride in solution. It has been shown that the presence of calcium in saliva reduces the concentration of measurable free fluoride in solution (by as much as 137 ppm). Although the effect of presence of Ca

Indexed as

artificial salivacalcium ionsdental gelsdesensitizing gelsfluoridein vitro

Identifiers

PMID42500490
PMCPMC13395941

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.