Evidence map›Paper›PMID 42500516›Full record

ArticleFrontiers in medicine2026

Structural brain changes, cerebral oxygenation, and cognitive function in hemodialysis patients: a cross-sectional study.

Martin Michna, Romana Burgetova, Karin Kremenova, Andrea Burgetova, Jan Krasensky, Jiri Lukavsky, Barbora Szonowska, Ivan Rychlik, Hana Malikova, Jan Malik

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin MichnaDepartment of Radiology and Nuclear Medicine, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czechia.
Romana BurgetovaDepartment of Radiology and Nuclear Medicine, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czechia.
Karin KremenovaDepartment of Radiology and Nuclear Medicine, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czechia.
Andrea BurgetovaDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Jan KrasenskyDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Jiri LukavskyFaculty of Arts, Charles University, Prague, Czechia.
Barbora SzonowskaFresenius Medical Care, Kralovske Vinohrady, Prague, Czechia.
Ivan RychlikDepartment of Internal Medicine, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czechia.
Hana MalikovaDepartment of Radiology and Nuclear Medicine, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czechia.
Jan MalikThird Department of Internal Medicine, General University Hospital in Prague, First Faculty of Medicine, Charles University, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive impairment is frequent in end-stage kidney disease (ESKD) patients, who also have brain structural changes and reduced regional cerebral oxygenation (rSO2). However, the relationship between these parameters remains insufficiently explored. The primary aim of this study was to compare cognition, brain structural changes and cerebral oxygenation between hemodialysis (HD) patients and healthy controls. The secondary aim was to assess the relationship between cerebral oxygenation, cognitive performance and brain morphometric parameters in HD patients. Methods: In this cross-sectional study, we enrolled 44 HD patients (24 males, 20 females; mean age 72.5 ± 17.5 years) and 24 healthy controls of similar age. All patients had received HD for more than three months. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Frontal lobe oxygenation was measured with the INVOS 5100C Oximetry system. Brain morphology was evaluated using MRI on a Magnetom Sola 1.5 T scanner, processed with MorphoBox software. Results: The HD group showed lower rSO2 ( Conclusion: HD patients had impaired cognition, lower cerebral oxygenation, and marked structural brain changes. However, regional frontal cerebral hypoxia was not associated with cognitive decline or brain structural changes in HD patients.

Indexed as

atrophyCKDcognitionhemodialysisoxygenation

Identifiers

PMID42500516
PMCPMC13396127

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.