ArticleFrontiers in medicine2026
Gastrointestinal endoscopy for physiological assessment in functional gastrointestinal disorders: a perspective.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The diagnosis of functional gastrointestinal disorders, now conceptualized as disorders of gut-brain interaction (DGBI), has long relied on symptom-based criteria. Gastrointestinal endoscopy, meanwhile, has been largely confined to the exclusion of organic pathology. This exclusionary logic has led to a systematic underestimation of the diagnostic value embedded in endoscopically normal findings. Here we propose a fundamental repositioning of the endoscope from a static morphological exclusion tool into a dynamic physiological assessment platform. By integrating real-time intraluminal functional imaging, optical biopsy of mucosal microarchitecture, neuro-immune fluorescence molecular imaging, and intraluminal environmental monitoring, this platform enables the
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