Evidence map›Paper›PMID 42500528›Full record

SynthesisFrontiers in medicine2026

Efficacy of hormone therapy and phytoestrogens on the psychological symptoms of menopausal women: a systematic review, meta-analysis, and trial sequential analysis.

Mengna Shou, Mengfei Ye, Chunhua Lou, Xinyi Chen, Yiying Yao, Junwei Yan, Wenchao Zhou, Zimu Fu, Zheng Liu

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengna Shou *Department of Women's Health, Shaoxing Maternity and Child Healthcare Hospital, Maternity and Child Healthcare Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang, China.
Mengfei Ye *Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center of Shaoxing University, Shaoxing, Zhejiang, China.
Chunhua LouDepartment of Women's Health, Shaoxing Maternity and Child Healthcare Hospital, Maternity and Child Healthcare Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang, China.
Xinyi ChenDepartment of Pharmacology, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.
Yiying YaoDepartment of Pharmacology, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.
Junwei YanDepartment of Blood Transfusion, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China.
Wenchao ZhouDepartment of Gynecology, Cixi People's Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.
Zimu FuDepartment of Women's Health, Shaoxing Maternity and Child Healthcare Hospital, Maternity and Child Healthcare Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang, China.
Zheng LiuDepartment of Pharmacology, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The efficacy of hormone therapy and phytoestrogens in reducing psychological symptoms of menopausal women has generated substantial debate. We aimed to evaluate the effectiveness of hormone therapy and phytoestrogens for psychological symptoms. Methods: We conducted a comprehensive search of multiple academic databases, including EMBASE, Cochrane Library, Web of Science, PubMed, and PsycINFO. The inclusion criteria were limited to randomized controlled trials (RCTs) published up to March 1, 2026. Hedge's Results: We analyzed the participant data from 51 RCTs of hormone therapy ( Conclusion: Hormone therapy and phytoestrogens alleviated psychological symptoms in menopausal women, but their effects differed by symptoms. The therapeutic strategy should be adopted based on individual patient's specific characteristics. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, Identifier: CRD42024533658.

Indexed as

hormone therapymenopausemeta-analysisphytoestrogenspsychological

Identifiers

PMID42500528
PMCPMC13395877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.