SynthesisFrontiers in medicine2026
Effects of intranasal dexmedetomidine on postoperative sleep quality: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative sleep disturbance is common in surgical patients and may slow recovery. Dexmedetomidine has a sleep like sedative effect, and intranasal administration provides a convenient and non-invasive route. The aim of our study was to evaluate the effect of intranasal dexmedetomidine on postoperative sleep quality in adult surgical patients. Methods: We performed a systematic review and meta-analysis of randomized controlled trials. PubMed, the Cochrane Library and Embase were searched to May 20, 2026. Intranasal dexmedetomidine was compared with placebo or other controls. Subjective and objective sleep outcomes, sleep disturbance and adverse events were analysed using standard meta-analytic methods. Subgroup analyses were further performed according to the route, timing, and duration of administration, as well as patient characteristics, surgical type, anesthesia type, and evaluation scales. Results: 15 trials were included. For subjective scores where a lower value means better sleep, intranasal dexmedetomidine improved postoperative sleep compared with controls (SMD = -1.29, 95% CI [-1.80, -0.77], Conclusion: Intranasal dexmedetomidine may improve short-term postoperative sleep, but evidence is limited and more high-quality trials are needed. Systematic review registration: PROSPERO 2025 CRD420251186146, Available from https://www.crd.york.ac.uk/PROSPERO/view/CRD420251186146.
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