ArticleFrontiers in medicine2026
Association of a novel meibomian gland dysfunction composite score with corneal nerve parameters and ocular surface symptoms in dry eye disease.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To construct a composite meibomian gland dysfunction (MGD) score integrating gland dropout, expressibility, and meibum quality, and to investigate its associations with corneal nerve parameters, subjective symptoms, and ocular surface signs in patients with dry eye disease (DED). Methods: This cross-sectional study included 137 DED patients (274 eyes). MGD composite score (0-9) was calculated as the sum of averaged upper/lower eyelid scores for dropout (0-3), expressibility (0-3), and meibum quality (0-3). Corneal nerve parameters (length, width, reflectivity, microneuroma count) were assessed by Results: MGD composite score positively correlated with OSDI ( Conclusion: The MGD composite score effectively reflects disease severity. Corneal nerve length is strongly associated with the relationship between MGD signs and subjective symptoms, providing a structural basis for understanding symptom-sign discordance in DED.
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