Sustained low micromolar hydrogen peroxide exposure induces sequential red blood cell dysfunction.

Jin Hyen Baek, Matthew C Williams, Sirsendu Jana, Xiaoyuan Zhang, Felice D'Agnillo

Abstract read

In one paragraph

Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jin Hyen Baek *Laboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, United States.

Matthew C Williams *Laboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, United States.

Sirsendu JanaLaboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, United States.

Xiaoyuan ZhangLaboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, United States.

Felice D'AgnilloLaboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Red blood cells (RBCs) are continuously exposed to oxidative stress throughout their lifespan and during Methods: We employed a glucose oxidase (GX)-based system to generate sustained hydrogen peroxide (H Results: Sustained H Discussion: These findings define a temporal hierarchy of oxidative injury under physiologically relevant conditions and demonstrate that vesiculation and PS externalization are mechanistically uncoupled under sustained oxidative stress. This model provides a framework for identifying early biomarkers of RBC dysfunction that may guide the development of targeted interventions to optimize blood storage and mitigate oxidative injury.

Indexed as

biomarkerserythrocyte deformabilityglutathione depletionhemoglobin oxidationmembrane integrityoxidative stressphosphatidylserinevesiculation

Identifiers

PMID42500600

DOI10.3389/fphys.2026.1860905

PMCPMC13397108

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.