ArticleCurrent microbiology2026
Combined Supplementation with Streptococcus Thermophilus Yilife-SST 01 and Bifidobacterium Bifidum BL-99 Mitigates Unloading-Induced Osteoporosis in Rats.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
Abstract
Probiotics have emerged as promising modulators of bone metabolism. This study evaluated the bone-protective effects of Streptococcus thermophilus Yilife-SST01 alone or in combination with Bifidobacterium bifidum BL-99 using MC3T3-E1 osteoblasts and a hindlimb unloading-induced osteoporosis model in Sprague-Dawley rats. S. thermophilus Yilife-SST01 promoted osteoblast mineralization and significantly inhibited osteoclast activity in both cancellous and cortical bone. Micro-CT analysis demonstrated marked improvements in bone microarchitecture, with bone mineral density increasing by 38.70% in the SST01 group and by 78.30% in the combined treatment group. Probiotic supplementation also increased fecal short-chain fatty acids, particularly butyrate and propionate, and reduced unloading-induced inflammatory cytokines, including TNF-α, IL-6, IL-1β, and IL-10. Whole-genome analysis confirmed the safety of both probiotic strains, with no classical virulence or acquired antimicrobial resistance genes detected. These findings indicate that S. thermophilus Yilife-SST01, especially when combined with B. bifidum BL-99, effectively alleviates unloading-induced osteoporosis by promoting bone formation, suppressing bone resorption, enhancing SCFA production, and modulating inflammatory responses, supporting its potential as a probiotic strategy for improving bone health.
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Registered trials
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