ArticleNeuroradiology2026
Hippocampal microstructural alterations in temporal lobe epilepsy with hippocampal sclerosis assessed using diffusion kurtosis imaging.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to assess hippocampal microstructural alterations in patients diagnosed with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and to evaluate the diagnostic utility of diffusion kurtosis imaging (DKI) in this population.
methodsA total of 53 patients with TLE-HS and 53 healthy controls (HC) underwent brain magnetic resonance imaging, including standard sequences and DKI acquisition. Bilateral hippocampi were defined as regions of interest. DKI-derived parameters and the FLAIR signal intensity ratio (R
resultsThe hippocampus on the affected side in patients with TLE-HS demonstrated significantly increased mean diffusivity, axial diffusivity, and radial diffusivity, along with significantly decreased axial kurtosis (AK), mean kurtosis (MK), and radial kurtosis, when compared with both the unaffected hippocampus and the hippocampi of the HC group (all p < 0.05). No significant differences in fractional anisotropy (FA) values were observed between the affected hippocampus and either the unaffected side or the HC group (p > 0.05); however, FA values in the unaffected hippocampus differed significantly from those in of the HC group (p < 0.05). In TLE patients, the lateralization index of DKI parameters and R
conclusionDKI-derived metrics provided sensitive indicators of hippocampal microstructural disruption in unilateral TLE-HS. These findings support the potential of DKI as a valuable adjunctive tool in the evaluation of hippocampal integrity in TLE-HS.
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