Evidence map›Paper›PMID 42501120›Full record

ArticleLasers in medical science2026

Comparative biomolecular analysis of normal and healed skin tissue from diabetic and non-diabetic rats using Raman spectroscopy.

Willy Leite Lima, Giovanna Garcia Vieira, Luciano Gonçalves da Nóbrega, Larissa Emily de Almeida Maciel, Bruno Araújo Serra Pinto, Landulfo Silveira, Thaís Porto Amadeu, Nilton Maciel Mangueira

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Willy Leite LimaPost-Graduate Program in Medical Sciences, Rio de Janeiro State University - UERJ, RJ, Rio de Janeiro, Brazil.
Giovanna Garcia VieiraSpecial Coordination of Morphology, Federal University of Maranhão - UFMA, MA, São Luís, Brazil.
Luciano Gonçalves da NóbregaAnhembi Morumbi University - UAM, SP, São Paulo, Brazil.
Larissa Emily de Almeida MacielSchool of Medicine, University Center of Maranhão - CEUMA, MA, São Luís, Brazil.
Bruno Araújo Serra PintoSpecial Coordination of Morphology, Federal University of Maranhão - UFMA, MA, São Luís, Brazil.
Landulfo SilveiraAnhembi Morumbi University - UAM, SP, São Paulo, Brazil. landulfo.silveira@gmail.com.
Thaís Porto AmadeuPost-Graduate Program in Medical Sciences, Rio de Janeiro State University - UERJ, RJ, Rio de Janeiro, Brazil.
Nilton Maciel MangueiraPost-Graduate Program in Medical Sciences, Rio de Janeiro State University - UERJ, RJ, Rio de Janeiro, Brazil. nm.mangueira@ufma.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia that disrupts skin repair through alterations in tissue biochemical composition and structural organization. This study compared Raman spectral profiles of normal and healed skin tissue in non-diabetic (Non-Db) and diabetic (Db) Wistar rats, based on the hypothesis that diabetes alters skin molecular composition during healing. Twelve Wistar rats were divided into Non-Db and Db groups (n = 6 per group). DM was induced by of alloxan monohydrate injection (150 mg/kg). Dorsal skin excision was performed under anesthesia on day 0 (normal tissue) and day 14 (healed tissue), resulting in 24 samples. Raman spectra were acquired (830 nm excitation, 400-1800 cm

Indexed as

Diabetes Mellitus, ExperimentalSkinSpectrum Analysis, RamanWound HealingAmino AcidsAnimalsCollagenElastinKeratinsMalePrincipal Component AnalysisRatsRats, WistarAmino AcidsCollagenElastinKeratinsBiochemical compositionCharacterizationDiabetesHealingPrincipal component analysisRaman spectroscopyRat skin tissue

Identifiers

PMID42501120
PMCPMC13401533

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.