Evidence map›Paper›PMID 42501227›Full record

ArticleNeuroscience bulletin2026

Acute Stress Drives Adaptive Anxiety via Excitatory-Inhibitory Imbalance in the Prefrontal-Amygdala Circuit in Male Mice.

Jia-Xin Zou, En Cao, Zhi-Hao Wang, Rui Han, Xing-Yan Lu, Cheng-Yuan Huang, Xia Qin, Wei-Zhu Liu, Wen-Hua Zhang, Bing-Xing Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia-Xin Zou *Department of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
En Cao *Department of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
Zhi-Hao Wang *Department of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
Rui HanQueen Mary School, Nanchang University, Nanchang, 330001, China.
Xing-Yan LuDepartment of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
Cheng-Yuan HuangDepartment of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
Xia QinJiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.
Wei-Zhu LiuDepartment of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China. ndyfy07457@ncu.edu.cn.ORCID http://orcid.org/0009-0000-3564-0831
Wen-Hua ZhangDepartment of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China. whzhang@ncu.edu.cn.ORCID http://orcid.org/0000-0003-0230-9856
Bing-Xing PanDepartment of Pathology, The First Affiliated Hospital and Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China. panbingxing@ncu.edu.cn.ORCID http://orcid.org/0000-0001-6404-4019

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute stress rapidly reshapes brain function to promote adaptive behavioral responses. Although dysfunction of the medial prefrontal cortex (mPFC)-amygdala circuit is well established in chronic stress-related anxiety, its role in acute adaptive anxiety remains unresolved. Here, using an acute restraint stress (ARS) model in male mice, we identified temporally restricted, projection-specific recruitment of dorsomedial prefrontal cortex (dmPFC) circuitry that regulates acute anxiety-like behavior. ARS selectively increased the activity of dmPFC projection neurons (PNs) at 2 h, but not 24 h post-stress, with minimal ventromedial prefrontal cortex engagement. This transient activation was confined to basolateral amygdala-projecting neurons (dmPFC

Indexed as

AmygdalaAnxietyPrefrontal CortexStress, PsychologicalAnimalsMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsRestraint, PhysicalAcute stressAnxietyExcitatory-inhibitory balanceNeural circuitPrefrontal cortex

Identifiers

PMID42501227
PMCPMC13642866

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.