ArticleSTAR protocols2026
Protocol to induce memory generalization and stress-like behaviors without memory strengthening using contextual fear conditioning in mice.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Over-generalization of negative memory is common in psychiatric disorders, including depression and anxiety. Here, we present a protocol to dissociate memory generalization from memory strengthening and induce lasting stress-related behavioral alterations using contextual fear conditioning in adult mice. We describe the steps for repeated conditioning in identical or distinct contexts, followed by memory testing and behavioral assays of stress-related phenotypes. This protocol enables the investigation of the behavioral and biological mechanisms underlying pathological memory generalization and its consequences. For complete details on the use and execution of this protocol, please refer to Cheng et al.
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