Evidence map›Paper›PMID 42501332›Full record

ArticleCell reports2026

Stimulus-dependent dopamine dynamics from locus coeruleus axons.

Avi Matarasso, Itzel Rodriguez Reyes, Elena Seaholm, Ashritha Cheeyandira, Michael J Seibert, Suchitha Jagalur, Sean C Piantadosi, Li Li, Yulong Li, David Weinshenker and 1 more

Abstract read
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In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Avi MatarassoDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA.
Itzel Rodriguez ReyesCenter for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Biology, University of Washington, Seattle, WA 98195, USA.
Elena SeaholmDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA; Center for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA.
Ashritha CheeyandiraCenter for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Biology, University of Washington, Seattle, WA 98195, USA.
Michael J SeibertDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA.
Suchitha JagalurCenter for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Biology, University of Washington, Seattle, WA 98195, USA.
Sean C PiantadosiDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA.
Li LiDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA; Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98105, USA.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
David WeinshenkerDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Michael R BruchasDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for the Neurobiology of Addiction, Pain and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: mbruchas@uw.edu.

Funding

Decoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3M
NIMH NIH HHS R01 MH112355
6 · The paper itself

Abstract

Arousal is essential for survival, and maladaptive arousal processing leads to an inability to focus, anxiety-like behavior, and dysregulated affective states. Norepinephrine (NE) is known to regulate anxiety, arousal, and learning through locus coeruleus (LC) projections throughout the brain. Evidence for co-release of the NE precursor and neurotransmitter dopamine (DA) from LC neurons has been accumulating for years, yet definitive measures of DA release across regions, stimulus paradigms, and behaviors associated with the LC-NE system remain controversial. Here, we identified the physiological and behavioral properties that evoke DA release from LC axon terminals. Using concomitant approaches, we inhibited the LC and ventral tegmental area (VTA) to selectively isolate the contributions of LC-derived DA release. Together these findings establish the constraints by which LC neurons release DA in a modality-dependent manner.

Indexed as

amygdalaCP: neurosciencedopaminefiber photomeer photometryhippocampusLocus coeruleusneuromodulationneurotransmitter biosensorstrynorpinephrineoptogenetics

Identifiers

PMID42501332

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.