Evidence map›Paper›PMID 42502268›Full record

ReviewRegenerative biomaterials2026

Three-dimensional bioprinted organoids: advances and clinical translation.

Yi Zhang, Zhen Huang, Beichen Wang, Bing Li, Yunfeng Yang

Abstract readReview
In one paragraph

Review in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi ZhangDepartment of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Zhen HuangDepartment of Orthopedics, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Beichen WangDepartment of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Bing LiDepartment of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yunfeng YangDepartment of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-dimensional (3D) bioprinting enables the precise fabrication of complex tissue constructs by depositing living cells, biomaterials, and bioactive factors in a spatially controlled manner. Concurrently, organoids-self-organizing 3D cellular structures that recapitulate key aspects of organ architecture and function-have revolutionized biomedical research by providing physiologically relevant models for disease modeling, drug screening, and regenerative medicine. The convergence of 3D bioprinting and organoid technology represents a significant advancement, offering new opportunities for personalized medicine and tissue engineering. This review examines the current state of 3D bioprinted organoids, encompassing bioprinting techniques, bio-ink development, and diverse clinical applications spanning oncology (patient-derived tumor organoids for predicting therapy response in selected gastrointestinal cancers), regenerative medicine (bioprinted bone, cartilage, cardiac, and skin constructs), drug discovery (hepatotoxicity and nephrotoxicity screening platforms), and personalized therapeutics. We discuss technological advances supporting translational development, while distinguishing clinically validated patient-derived tumor organoid evidence from preclinical and proof-of-concept regenerative applications, and critically analyze the challenges that must be addressed for widespread clinical adoption. Finally, we provide perspectives on future directions, including the integration of artificial intelligence, multiorganoid systems, and regulatory pathways that will shape the next generation of 3D bioprinted organoids for clinical use.

Indexed as

3D bioprintingbio-inksclinical translationorganoidspersonalized medicineregenerative medicinetissue engineering

Identifiers

PMID42502268
PMCPMC13401513

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.