Two-hour glucose reductions and baseline levels for effective prevention of type 2 diabetes in individuals with impaired glucose tolerance: An evidence synthesis and meta-regression analysis.

Kotoba Okuyama, Anna Tsutsui, Yoshitaka Murakami

Abstract read

In one paragraph

Article in Preventive medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Kotoba OkuyamaDepartment of Medical Statistics, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan.

Anna TsutsuiDepartment of Medical Statistics, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan.

Yoshitaka MurakamiDepartment of Medical Statistics, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To identify the optimal 2-h glucose reduction and baseline level for preventing progression from impaired glucose tolerance to type 2 diabetes using meta-regression. Methods: We systematically reviewed randomized clinical trials of lifestyle modifications and/or anti-hyperglycemic medications reporting both 2-h glucose and diabetes prevention in impaired glucose tolerance. PubMed (1997), Cochrane Library (1995), and Ichushi-Web (Japanese medical literature database; 2000) were searched from inception through January 26, 2025. A meta-regression model examined log-transformed hazard ratios for diabetes progression, with 2-h glucose reduction and baseline level as predictors. Results: From 1372 candidates, 32 studies ( Conclusions: This meta-regression analysis demonstrates that early and minimal interventions for impaired glucose tolerance are optimal, suggesting that its timely detection is vital for diabetes prevention.

Indexed as

Impaired glucose toleranceMeta-regression analysisPreventionRisk reductionType 2 diabetes mellitus

Identifiers

PMID42502745

DOI10.1016/j.pmedr.2026.103571

PMCPMC13400255

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.