Evidence map›Paper›PMID 42503190›Full record

ArticleChembiochem : a European journal of chemical biology2026

Azurins With Tunable Reduction Potentials as Redox Mediators for Extracellular Electron Transfer.

Alexis J Holwerda, Jing-Xiang Wang, Yang Gao, Yi Lu, Benjamin K Keitz

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexis J HolwerdaInterdisciplinary Life Sciences Graduate Program, The University of Texas at Austin, Austin, Texas, USA.ORCID https://orcid.org/0000-0002-0911-3533
Jing-Xiang WangDepartment of Chemistry, The University of Texas at Austin, Austin, Texas, USA.
Yang GaoMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Yi LuInterdisciplinary Life Sciences Graduate Program, The University of Texas at Austin, Austin, Texas, USA.
Benjamin K KeitzInterdisciplinary Life Sciences Graduate Program, The University of Texas at Austin, Austin, Texas, USA.

Funding

Therapeutic and Catalytic Applications of Electroactive BacteriaR35GM156283 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BENJAMIN KEITH KEITZ · 2025 to 2026
$644k
Air Force Office of Scientific Research FA9550-24-1-0273National Science Foundation 1944334National Science Foundation CHE-2420683NIH HHS 1 S10 OD021508-1NIH HHS R35GM156283Welch Foundation
6 · The paper itself

Abstract

Electroactive microbes, such as Shewanella oneidensis MR-1, have been harnessed for a variety of bioelectrochemical and catalytic applications. Efforts to improve the electrochemical performance of these bacteria have included the use or biological synthesis of small-molecule redox mediators, such as flavins. However, limited redox range and complex biosynthetic pathways have restricted their broad applications. To overcome these limitations, we report the use of azurin, a cupredoxin commonly used as electron transfer proteins, as a redox mediator for S. oneidensis extracellular electron transfer (EET). We showed that S. oneidensis reduces four different azurin variants, spanning a 440 mV range, and that the reduction rate is dependent on azurin concentration (K

Indexed as

AzurinShewanellaBiocatalysisBioelectric Energy SourcesElectron TransportOxidation-ReductionAzurinazurinbiocatalysisextracellular electron transfermetalloenzymesShewanella oneidensis

Identifiers

PMID42503190
PMCPMC13401956

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.