Evidence map›Paper›PMID 42503237›Full record

ArticleAdvanced healthcare materials2026

In Situ Click Chemistry Forming pH/ROS-Responsive and Antifouling Hydrogel to Prevent Intrauterine Adhesion and Restore Fertility.

Jiepei Lin, Min You, Xinbei Lv, Vanessa Vimbiso Mavhunure, Qinying Wang, Ziqing Tang, Hui Yu, Qiang Chen, Feng Lin, Huijuan Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiepei LinDepartment of Gynecology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Wenzhou, Zhejiang, P. R. China.
Min YouWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, P. R. China.
Xinbei LvDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Vanessa Vimbiso MavhunureDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Qinying WangDepartment of Gynecology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Wenzhou, Zhejiang, P. R. China.
Ziqing TangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, P. R. China.
Hui YuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, P. R. China.
Qiang ChenWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, P. R. China.ORCID https://orcid.org/0000-0002-8592-9518
Feng LinDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Huijuan HuDepartment of Gynecology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Wenzhou, Zhejiang, P. R. China.

Funding

National Natural Science Foundation of China 52573132National Natural Science Foundation of China 82572289National Natural Science Foundation of China U24A20506Wenzhou Basic Public Welfare Science Research Project Y2023142Zhejiang Provincial Natural Science Foundation of China LTGY24E030002
6 · The paper itself

Abstract

Intrauterine adhesion (IUA) leads to abortion and infertility that poses a severe threat to female reproductive and psychological health. The highly oxidative microenvironment and fibrosis of the endometrial wound are critical factors driving IUA pathogenesis. Here, a pH and reactive oxygen species (ROS) dual-responsive hydrogel (DRH) with antifouling property, which could be gelated in situ click chemistry, was developed to effectively treat IUA via anti-oxidative and anti-fibrosis. This DRH was prepared by a dual-crosslinking structure, which was based on the thiol-ene click chemistry reaction of poly(ethylene glycol) diacrylate (PEGDA), 4-arm poly(ethylene glycol) acrylate (4-arm-PEG-AC) and dithiothreitol (DTT), coupled with borate ester bonds between borax and DTT. This DRH presented excellent antifouling and good ROS scavenging, which reduced protein and cell adhesion, as well as alleviated oxidative stress. Additionally, the DRH also exhibited pH and ROS responsiveness, enabling degradation in the intrauterine microenvironment. In the rat endometrial injury model, the DRH successfully exerted an effective therapeutic effect on IUA, and thus eventually restored fertility by attenuating the endometrial oxidative damage, inhibiting the activation of myofibroblasts, and reducing epithelial-mesenchymal transition.

Indexed as

BiofoulingClick ChemistryFertilityHydrogelsReactive Oxygen SpeciesAnimalsCell AdhesionEndometriumFemaleHumansHydrogen-Ion ConcentrationOxidative StressPolyethylene GlycolsRatsRats, Sprague-DawleyTissue AdhesionsHydrogelsPolyethylene GlycolsReactive Oxygen Speciesanti‐fibrosisantifouling hydrogelanti‐oxidationintrauterine adhesionpH/ROS‐responsive

Identifiers

PMID42503237
PMCPMC13495838

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.