Evidence map›Paper›PMID 42503550›Full record

ArticleAnnals of biomedical engineering2026

Patient-Specific Fluid-Structure Interaction Simulations Suggest Wall-Shear-Stress-Related Biomarkers in Type B Dissection Associated with Marfan Syndrome.

Yufan Wu, Krashn Kr Dwivedi, Hadi Wiputra, Marisa S Bazzi, Alan C Braverman, Victor H Barocas, Jessica E Wagenseil

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In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yufan WuDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., MSC 1185-208-125, Saint Louis, MO, 63130, USA.
Krashn Kr DwivediDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., MSC 1185-208-125, Saint Louis, MO, 63130, USA.
Hadi WiputraDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Marisa S BazziDepartment of Pediatrics, Stanford University, Palo Alto, CA, USA.
Alan C BravermanDepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Victor H BarocasDepartment of Pediatrics, Stanford University, Palo Alto, CA, USA.
Jessica E WagenseilDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., MSC 1185-208-125, Saint Louis, MO, 63130, USA. jessica.wagenseil@wustl.edu.ORCID http://orcid.org/0000-0001-7972-448X

Funding

Theranostic approach to treat abdominal aortic aneurysmsR01HL133662 · NHLBI · CLEMSON UNIVERSITY · PI Naren R Vyavahare · 2017 to 2026
$4.1M
Complementary animal and computational models for biomarker identification in ascending thoracic aortic aneurysmR01HL164800 · NHLBI · WASHINGTON UNIVERSITY · PI VICTOR H BAROCAS, Jessica Wagenseil · 2022 to 2026
$3.2M
Investigating altered smooth muscle cell mechanotransduction as a cause of supravalvular aortic stenosisR01HL166448 · NHLBI · WASHINGTON UNIVERSITY · PI Jessica Wagenseil · 2023 to 2026
$1.6M
American Heart Association 25POST1379021NHLBI NIH HHS R01 HL133662NHLBI NIH HHS R01HL133662NHLBI NIH HHS R01 HL164800NHLBI NIH HHS R01HL164800NHLBI NIH HHS R01 HL166448NHLBI NIH HHS R01HL166448
6 · The paper itself

Abstract

purposeChronic type B dissection is a cardiovascular complication that occurs in the descending aorta (DSC), involving a tear at the inner wall that is present for more than three months. It can cause progressive aortic dilation, organ malperfusion, and further tearing of the aortic wall. Connective tissue disorders, such as Marfan syndrome (MFS), are associated with chronic type B dissection. Aortic diameter and growth rate are the current surveillance metrics and surgical/interventional criteria for chronic type B dissection. However, they are geometric metrics and fail to capture the hemodynamic changes that may contribute to an increased risk of adverse cardiovascular events. This study aimed to assess changes in aortic geometry and hemodynamics and investigate potential wall-shear-stress-related biomarkers to improve clinical treatment and prognostic assessment of chronic type B dissection.

methodsFluid-structure interaction simulations on MFS patient images before and after type B dissection were performed. Shear-stress-related metrics were quantified, and their variation over the DSC length was correlated with geometrical parameters that have been used as measures of disease progression.

resultsPatterns of variation over the DSC length for endothelial cell activation potential and relative residence time, two metrics that combine oscillatory shear index and time-averaged wall shear stress, correlated with maximum DSC diameter before and after dissection. Oscillatory shear index variation over the DSC length correlated with the false lumen volume index after dissection.

conclusionShear-stress-related metrics hold promise as noninvasive biomarkers for chronic type B dissection surveillance and management in MFS.

Indexed as

Fluid-structure interaction (FSI)Marfan syndrome (MFS)Shear stressType B dissection

Identifiers

PMID42503550
PMCPMC13520064

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.