Evidence map›Paper›PMID 42503576›Full record

ReviewThe European journal of neuroscience2026

Targeting the Microbiota-Gut-Brain Axis: Emerging Nanomedicine Approaches for Neurodegenerative Diseases.

Reda M Mansour, Khaled M Alam-ElDein, Sherif S Abdel Mageed, Gharieb S El-Sayyad, Aml Ghanem, Abanoub A S Shaker, Osama A Mohammed, Dina Adel Attallah Farag, Mariam Abdelnaby, Amira Hathout and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Reda M MansourZoology and Entomology Department, Faculty of Science, Capital University, Helwan, Egypt.ORCID https://orcid.org/0000-0002-5546-9020
Khaled M Alam-ElDeinMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt.ORCID https://orcid.org/0009-0002-1140-8338
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo, Badr City, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0702-5035
Gharieb S El-SayyadDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0001-5410-7936
Aml GhanemSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt.
Abanoub A S ShakerSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt.ORCID https://orcid.org/0000-0002-3025-6504
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, Saudi Arabia.ORCID https://orcid.org/0000-0001-9712-9609
Dina Adel Attallah FaragBiotechnology and Molecular Biology Department, School of Biotechnology, Badr University In Assiut (BUA), Assiut, Egypt.
Mariam AbdelnabyMoscow Center for Advanced Studies, Moscow, Russia.
Amira HathoutMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt.
Rana Y AdelazizPharmaceutical Biotechnology Department, School of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt.
Nada E AhmedMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt.
Marwa Yousry A MohamedDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Ahmed S DoghishBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.ORCID https://orcid.org/0000-0002-0136-7096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microbiota-gut-brain axis (MGBA) is a bidirectional relationship between the gut microbiota (GM) and the brain, where the GM affects the gastrointestinal tract (GIT) and the central nervous system (CNS), and vice versa. Microbiotas are important for several vital body processes, including metabolism, immunity, and homeostasis. The MGBA has three main pathways: the vagal nerve mechanism, the immune-related mechanism, and the neuroendocrine mechanism. GM imbalance, known as dysbiosis, affects the GIT, the brain, and the CNS. Furthermore, dysbiosis is linked to several neurological disorders such as Alzheimer's (AD), Parkinson's (PD), depression, autism spectrum disorder (ASD), and multiple sclerosis (MS). Studying MGBA gives researchers new therapeutic ideas using microbiota. Using special diets rich in fiber and probiotics, in addition to fecal microbiota transplantation (FMT), is being studied as a new therapy for MGBA. From the point of view that these therapeutic interventions maintain microbiota imbalance, which in turn will affect the brain and can relieve the neurological disorders caused by dysbiosis and MGBA.

Indexed as

BrainBrain-Gut AxisDysbiosisGastrointestinal MicrobiomeNanomedicineNeurodegenerative DiseasesAnimalsFecal Microbiota TransplantationHumansProbioticsdysbiosismicrobiota–gut–brain axis (MGBA)nanomedicineneurodegenerative diseasesneuroinflammation

Identifiers

PMID42503576
PMCPMC13402341

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.