Evidence map›Paper›PMID 42503636›Full record

ArticleBioconjugate chemistry2026

Organometallic Chemistry Approach to Peptide Tricycles.

Nima Adhami, Michael J P Rebelo, Rebecca A Jenkins, Eileen J Olivares, Rachel R Ogorzalek Loo, Songrong Qu, Melanie J Olivares, Reanne J Coutinho, Evan A Doud, Tyler A Kerr and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nima AdhamiDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.
Michael J P RebeloDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.
Rebecca A JenkinsDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.
Eileen J OlivaresDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0003-0627-2405
Rachel R Ogorzalek LooDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0002-0580-2833
Songrong QuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0002-1179-6468
Melanie J OlivaresThomas Lord Department of Computer Science, University of Southern California, Los Angeles, California90089, United States.
Reanne J CoutinhoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.
Evan A DoudDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0003-4561-4105
Tyler A KerrDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0002-0369-4883
Austin D ReadyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.
Yueying WangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0002-4204-0065
Brendan J MahoneyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.
Robert T ClubbDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0001-5718-3985
Joseph A LooDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0001-9989-1437
Jose A RodriguezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.
Alexander M SpokoynyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California90095, United States.ORCID 0000-0002-5683-6240

Funding

Inorganic Chemistry Tools for Bioconjugation, Recognition and ImagingR35GM124746 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Michael Spokoyny · 2017 to 2026
$4.0M
Micro Electron Diffraction of Toxic and/or Infectious Macromolecular NanoassembliesR35GM128867 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jose Alfonso Rodriguez · 2018 to 2026
$3.1M
Advancing Mass Spectrometry Analyses of Proteins, Assemblies, and ProteoformsR35GM145286 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A Loo · 2022 to 2026
$1.9M
David and Lucile Packard Foundation NANIGMS NIH HHS R35 GM124746NIGMS NIH HHS R35GM124746NIGMS NIH HHS R35 GM128867NIGMS NIH HHS R35GM128867NIGMS NIH HHS R35 GM145286NIGMS NIH HHS R35GM145286
6 · The paper itself

Abstract

Herein, we demonstrate how Au(III) organometallic chemistry offers the potential to streamline the generation of constrained peptide tricycles. By leveraging the chemoselectivity and ultrafast kinetics of tetrametallic Au(III)-based aryl reagents toward cysteine (Cys) bioconjugation, we have constructed a small library of constrained peptide tricycles. These tricycles can be synthesized and isolated in 25-55% yields from various tetracysteine-containing linear peptides. In all cases, tricyclization conversion occurs quantitatively under five min at sub-mM concentrations of the target peptide and proceeds under varied distributions of the four Cys residues in the target peptide sequence. Furthermore, by constraining various linear peptides around the aryl core of tetraphenylethylene, a common solid-state luminogen, we generate fluorescent macrocycles with robust solution-state emissive profiles. We evaluated the innate affinity of these fluorescent hybrid peptides toward cells, finding that they behave as highly selective luminogenic cell markers of cellular debris.

Indexed as

GoldPeptidesCyclizationCysteineHumansCysteineGoldPeptides

Identifiers

PMID42503636
PMCPMC13495551

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.