Evidence map›Paper›PMID 42503726›Full record

ArticleMagnetic resonance in medicine2026

Using Manganese-Enhanced DCE-MRI to Assess Blood-Cerebrospinal Fluid Barrier Transport.

Charith Perera, Zhiping Feng, Shereen Nizari, Phillip Muza, Christina Katsiva, Tammy L Kalber, Mark F Lythgoe, Ian F Harrison, Daniel J Stuckey, Jack A Wells

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charith PereraUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0009-0004-1291-2645
Zhiping FengUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0009-0007-1051-5541
Shereen NizariUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0002-7245-7435
Phillip MuzaUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0002-6146-9203
Christina KatsivaUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0009-0007-3604-6456
Tammy L KalberUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0002-3378-3748
Mark F LythgoeUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0002-4945-0171
Ian F HarrisonUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0003-1250-4911
Daniel J StuckeyUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0001-8888-627X
Jack A WellsUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID https://orcid.org/0000-0002-4171-3539

Funding

Alzheimer's Society AS-DRL-24-003AstronauTx Ltd.Brain Tumour Charity QfC_2018_10387British Council 31BX21DSKVBritish Heart Foundation FS/15/33/31608British Heart Foundation FS/SBSRF/21/31020British Heart Foundation PG/24/11864British Heart Foundation RM/17/1/33377Cancer Research UK 190133Eli Lilly & CompanyJohn Black Charitable Foundation A2200Medical Research Council MR/R026416/1Parkinson's UK DAA-25B-K-25-02Parkinson's UK SFEL-19-02Rosetrees TrustUCL Birkbeck MRC DTPWellcome TrustWellcome Trust 212937/Z/18/ZWellcome Trust 223808/Z/21/ZWellcome Trust 225345/Z/22/Z
6 · The paper itself

Abstract

purposeWe developed a dynamic, heavily T2-weighted (hT2w) FLAIR protocol to resolve acute Mn

methodshT2w-FLAIR DCE MRI was conducted in anesthetized C57BL/6 mice, receiving intravenous Mn

resultsMn

conclusionOur hT2w-FLAIR DCE-MRI approach captured the early BCSFB transport window for Mn

Indexed as

Blood-Brain BarrierCerebrospinal FluidDynamic Contrast Enhanced Magnetic Resonance ImagingMagnetic Resonance ImagingManganeseAnimalsChoroid PlexusContrast MediaHeterocyclic CompoundsMaleMiceMice, Inbred C57BLOrganometallic CompoundsContrast Mediagadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetateHeterocyclic CompoundsManganeseOrganometallic Compoundsblood cerebrospinal fluid barrier (BCSFB)braincerebrospinal fluid (CSF)choroid plexus (ChP)fluid‐attenuated inversion recovery (FLAIR)gadolinium‐based contrast agents (GBCA)high field (9.4 T)manganese‐enhanced MRI (MEMRI)mousepreclinical

Identifiers

PMID42503726
PMCPMC13527285

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.