Evidence map›Paper›PMID 42504398›Full record

ArticleGenes, brain, and behavior2026

Phenotypic Behavioural Effects of Genetic Deletion of the Vesicular Glutamate Transporter 3 in 5-Hydroxytryptamine Neurons.

L Sophie Gullino, Nida Chabbah, Spatika Jayaram, Raquel Pinacho, Salah El Mestikawy, Stéphanie Daumas, David M Bannerman, Trevor Sharp

Abstract read
In one paragraph

Article in Genes, brain, and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

L Sophie GullinoDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-9372-9957
Nida ChabbahSorbonne Université, INSERM, CNRS, Centre for Neuroscience (NeuroSU)- Institut de Biologie Paris Seine (IBPS), Paris, France.
Spatika JayaramDepartment of Pharmacology, University of Oxford, Oxford, UK.
Raquel PinachoDepartment of Experimental Psychology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-6417-5983
Salah El MestikawySorbonne Université, INSERM, CNRS, Centre for Neuroscience (NeuroSU)- Institut de Biologie Paris Seine (IBPS), Paris, France.ORCID https://orcid.org/0000-0002-6253-0002
Stéphanie DaumasSorbonne Université, INSERM, CNRS, Centre for Neuroscience (NeuroSU)- Institut de Biologie Paris Seine (IBPS), Paris, France.ORCID https://orcid.org/0000-0001-7048-7617
David M BannermanDepartment of Experimental Psychology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-3024-7595
Trevor SharpDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-7434-9713

Funding

French Ministry of ResearchMedical Research Council MR/N013468/1Oxford Medical Sciences Internal Fund: Pump-Priming by the Nuffield Benefaction for MedicineWellcome Institutional Strategic Support Fund (ISSF) 0005667Wellcome Trust
6 · The paper itself

Abstract

A major subpopulation of 5-hydroxytryptamine (5-HT) neurons expresses the vesicular glutamate transporter 3 (VGLUT3) allowing the co-release of glutamate. Previous evidence has implicated VGLUT3 in 5-HT neurons in mechanisms of anxiety and reward. Here we examined mice with a genetic loss of VGLUT3 targeted to 5-HT neurons (VGLUT3 cKO

Indexed as

Amino Acid Transport Systems, AcidicBehavior, AnimalSerotonergic NeuronsAnimalsAnxietyMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutPhenotypeRewardSerotoninAmino Acid Transport Systems, AcidicSerotoninSlc17a8 protein, mouse5‐HTanxietyglutamatelearningrewardserotoninVGLUT3

Identifiers

PMID42504398
PMCPMC13402935

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.