Evidence mapPaperPMID 42504657Full record

ArticleJournal of neurogastroenterology and motility2026

The Effects of Physical Activity on Functional Dyspepsia: A Mendelian Randomization and Randomized Controlled Study.

Zhongcao Wei, Zhiwei Tao, Yujie Hao, Na Liu, Jinhai Wang, Xin Xing

Abstract read
In one paragraph

Article in Journal of neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Physical Activity as a Therapeutic Strategy for Functional Dyspepsia.Journal of neurogastroenterology and motility · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhongcao WeiDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.ORCID https://orcid.org/0000-0001-8931-680X
Zhiwei TaoDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.
Yujie HaoDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.
Na LiuDepartment of Gastroenterology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan Province, China.ORCID https://orcid.org/0000-0003-3246-9674
Jinhai WangDepartment of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.ORCID https://orcid.org/0000-0003-1365-4727
Xin XingHealth Management Department, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.ORCID https://orcid.org/0000-0003-0161-2482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: : The relationship between physical activity (PA) and functional dyspepsia (FD) remains unclear due to a lack of robust evidence. We conducted a Mendelian randomization (MR) analysis to assess potential genetic associations, followed by a randomized controlled trial (RCT) assessing the therapeutic effects of moderate-intensity exercise in FD patients. Methods: : In the MR analysis, genetic variants associated with PA traits from genome-wide association studies were analyzed. For the RCT, 260 FD patients were randomized to moderate-intensity exercise intervention or a control group. The primary endpoint was the adequate relief rate of dyspeptic symptoms. Results: : Using MR, a potential inverse association of strenuous sports activity against the development of FD was estimated (inverse variance weighte OR = 0.92, 95% CI = 0.88-0.98, Conclusions: : PA, particularly moderate-intensity exercise, may reduce the risk of FD.

Indexed as

AssociationFunctional dyspepsiaMendelian randomizationPhysical activityRandomized controlled study

Identifiers

PMID42504657
PMCPMC13424849

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.