ArticleJournal of neurogastroenterology and motility2026
Ineffective Esophageal Motility and Its Predictors in Gastroesophageal Reflux Disease Patients with Pathologic Acid Exposure Time.
Article in Journal of neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/Aims: : Although gastroesophageal reflux disease (GERD) and ineffective esophageal motility (IEM) often coexist, the directionality of their relationship remains uncertain. Clarifying physiological predictors of IEM in GERD patients with objectively verified pathological acid exposure may facilitate more personalized treatment strategies. Methods: : This retrospective analysis included 289 patients with typical reflux symptoms and abnormal acid exposure (acid exposure time > 6%) confirmed by 24-hour pH-impedance monitoring. Esophageal motility was assessed using high-resolution manometry, while mucosal integrity was evaluated through distal mean nocturnal baseline impedance (MNBI). Patients were categorized into normal motility and IEM groups. Clinical, endoscopic, manometric, and impedance parameters were compared between the groups. Results: : IEM was identified in 41.5% of patients. Compared with those showing normal motility, the IEM group was older (median 51.5 vs 44 years, Conclusions: : In GERD patients with confirmed pathological acid exposure, IEM is common and associated with weakened LES pressure, delayed peristalsis, and reduced mucosal integrity. The link between low MNBI and IEM suggests an interaction between epithelial barrier dysfunction and esophageal motility, emphasizing the need for comprehensive functional evaluation in GERD management.
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